2026 MV HONDIUS CRUISE WATCH — 11 LINKED RECORDS · WHO8 CONFIRMED · 2 PROBABLE · 1 INCONCLUSIVE (U.S.)ANDES VIRUS · SOUTH AMERICAN ITINERARY
2026 MV HONDIUS CRUISE WATCH — 11 LINKED RECORDS · WHO8 CONFIRMED · 2 PROBABLE · 1 INCONCLUSIVE (U.S.)ANDES VIRUS · SOUTH AMERICAN ITINERARY
2026 MV HONDIUS CRUISE WATCH — 11 LINKED RECORDS · WHO8 CONFIRMED · 2 PROBABLE · 1 INCONCLUSIVE (U.S.)ANDES VIRUS · SOUTH AMERICAN ITINERARY
2026 MV HONDIUS CRUISE WATCH — 11 LINKED RECORDS · WHO8 CONFIRMED · 2 PROBABLE · 1 INCONCLUSIVE (U.S.)ANDES VIRUS · SOUTH AMERICAN ITINERARY
2026 MV HONDIUS CRUISE WATCH — 11 LINKED RECORDS · WHO8 CONFIRMED · 2 PROBABLE · 1 INCONCLUSIVE (U.S.)ANDES VIRUS · SOUTH AMERICAN ITINERARY
2026 MV HONDIUS CRUISE WATCH — 11 LINKED RECORDS · WHO8 CONFIRMED · 2 PROBABLE · 1 INCONCLUSIVE (U.S.)ANDES VIRUS · SOUTH AMERICAN ITINERARY
2026 MV HONDIUS CRUISE WATCH — 11 LINKED RECORDS · WHO8 CONFIRMED · 2 PROBABLE · 1 INCONCLUSIVE (U.S.)ANDES VIRUS · SOUTH AMERICAN ITINERARY
2026 MV HONDIUS CRUISE WATCH — 11 LINKED RECORDS · WHO8 CONFIRMED · 2 PROBABLE · 1 INCONCLUSIVE (U.S.)ANDES VIRUS · SOUTH AMERICAN ITINERARY
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Clinical

Testing

Hantavirus testing is coordinated through state and local public health departments and is not a standard outpatient lab. The right specimen, the right timing, and the right reporting path matter as much as the assay itself.

Key facts

Notifiable in U.S.
Yes
Primary specimen
Serum
First-line assay
IgM/IgG ELISA
Confirmatory
RT-PCR / IHC
Coordination
State / local health department
Single negative result
Does not rule out

Who coordinates testing

Clinicians do not order hantavirus testing the way they order a CBC. Suspected cases are coordinated through state or local public health departments, which route specimens to qualified laboratories and ensure surveillance reporting is triggered.

Common specimen options

The exact specimen depends on timing and clinical presentation.

  • Serum — most common; IgM/IgG ELISA is the first-line serologic assay.
  • Whole blood — for RT-PCR detection of viral RNA, particularly early in illness.
  • Tissue (autopsy / biopsy) — IHC of fixed tissue can confirm in fatal cases.
  • Convalescent serum — paired sera demonstrating IgG seroconversion can support confirmation.

Timing relative to symptoms

IgM is often detectable around the onset of HPS symptoms; IgG rises shortly after. RT-PCR is most useful early. A single negative test does not rule out hantavirus disease — repeat testing is part of the workflow when clinical suspicion is high.

Interpretation language

HantaScan does not collapse classifications: confirmed, probable, and inconclusive are kept separate even when the same individual moves between them as results return. A change in a record's classification is itself a signal worth tracking.

Reporting paths

Hantavirus infection is a nationally notifiable condition in the United States.

  • Clinicians report suspected cases to their state or local health department.
  • State labs route specimens upstream as needed for confirmation.
  • Confirmed cases flow into CDC's national surveillance system (NNDSS).

Related on HantaScan

Primary Sources

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